Out-of-control, trash-talking buddy cops Marcus Burnett and Mike Lowrey of the Miami Narcotics Task Force reunite, and bullets fly, cars crash and laughs explode as they pursue a whacked-out drug lord from the streets of Miami to the barrios of Cuba. But the real fireworks result when Marcus discovers that playboy Mike is secretly romancing Marcus’ sexy sister.

When the government puts all its rotten criminal eggs in one airborne basket, it's asking for trouble. Before you can say, "Pass the barf bag," the crooks control the plane, led by creepy Cyrus "The Virus" Grissom. Watching his every move is the just-released Cameron Poe, who'd rather reunite with his family.