BSAA Chris Redfield enlists the help of government agent Leon S. Kennedy and Professor Rebecca Chambers from Alexander Institute of Biotechnology to stop a death merchant with a vengeance from spreading a deadly virus in New York.

Picking up immediately after the events in Resident Evil: Retribution, Alice (Milla Jovovich) is the only survivor of what was meant to be humanity's final stand against the undead. Now, she must return to where the nightmare began - The Hive in Raccoon City, where the Umbrella Corporation is gathering its forces for a final strike against the only remaining survivors of the apocalypse.

A zombie attack brings chaos to Harvardville Airport. Leon Kennedy and Claire Redfield , who fought the sinister Umbrella Corporation during the Raccoon City tragedy 7 years ago, are back. In high-octane Resident Evil style, they're ready to battle a rogue warrior who is seeking revenge after his family was killed in Raccoon City. The deadly G-Virus is unleashed and a new mutated monster rampages.

In a world ravaged by a virus infection, turning its victims into the Undead, Alice continues on her journey to find survivors and lead them to safety. Her deadly battle with the Umbrella Corporation